Medicine

Molecular classification to fine-tune medical and radiotherapeutic decision-making in meningioma

.MacFeeters Hamilton Neuro-Oncology Plan, Princess Margaret Cancer Center, University Health And Wellness System and also University of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDivision of Neurosurgery, Division of Surgical Operation, Educational Institution of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehPrincess Margaret Cancer Cells Centre, Educational Institution Health And Wellness Network, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDalla Lana College of Hygienics, College of Toronto, Toronto, Ontario, CanadaOlli SaarelaNRG Oncology Statistics as well as Information Control Facility, Philly, , USAStephanie L. Pughu00c2 &amp u00c2 Minhee WonTemerty College of Medication, College of Toronto, Toronto, Ontario, CanadaZeel PatelNeurosurgery Specialists of Tulsa, Tulsa, OK, USAChristopher WilsonDepartment of Nerve Surgical Treatment, Keck College of Medicine of the University of Southern California, Los Angeles, CA, USAAaron Cohen-GadolDepartment of Nerve Surgery, Indiana University University of Medicine, Indianapolis, IN, USAMohamed A. ZaazoueDepartment of Orthopedic Surgical Operation, Washington College School of Medication in St. Louis, St. Louis, MONTH, USAMohamed A. ZaazoueGerman Cancer Cells Consortium (DKTK), DKFZ Companion Web Site Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiCluster of Superiority (EXC 2180) u00e2 $ Picture Directed and also Functionally Directed Tumor Therapiesu00e2 $, Eberhard Karls University Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiDepartment of Neurology and Interdisciplinary Neuro-Oncology, Center for Neuro-Oncology, Comprehensive Cancer Center, Hertie Principle for Scientific Human Brain Analysis, Eberhard Karls College Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh Tabatabai, u00c2 Sylvia C. Kurzu00c2 &amp u00c2 Paul PasslackDepartment of Neurosurgery, Facility for Neuro-Oncology, Comprehensive Cancer Facility, Eberhard Karls University Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyMarcos Tatagiba, u00c2 Felix Behling, u00c2 Mirjam Renovanz, u00c2 Jens Schittenhelmu00c2 &amp u00c2 Paul PasslackDepartment of Pathology, College of San Francisco, San Francisco, CA, USADamian A. Almiron BonninHuman The Field Of Biology Division, Fred Hutchinson Cancer Cells Facility, Seat, WA, USAEric C. HollandDepartment of Person Oncology, College of Wisconsin Hospitals and also Clinics, Madison, WI, USATim J. KruserCentral Mind Cyst Pc Registry of the USA, Hinsdale, IL, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanTrans Divisional Analysis Course (TDRP), Division of Cancer Cells Public Health and also Genes (DCEG), National Cancer Institute, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanCenter for Biomedical Informatics &amp Information Technology (CBIIT), National Cancer Cells Institute, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanPiedmont Human Brain Tumor Facility, Piedmonth Healthcare System, Atlanta Ga, GA, USAAndrew E. Sloanu00c2 &amp u00c2 Andrew E. SloanDepartment of Pathology, Northwestern University, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiLou &amp Jean Malnati Human Brain Tumor Institute at the Lurie Comprehensive Cancer Cells Center, Northwestern University, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiDepartment of Neurosurgery, Vanderbilt College Medical Facility, Nashville, TN, USASilky Chotaiu00c2 &amp u00c2 Lola B. ChamblessDepartment of Lab Medicine and Pathobiology, Educational Institution of Toronto, Toronto, Ontario, CanadaAndrew GaoDivision of Neurosurgery, University of British Columbia, Vancouver, British Columbia, CanadaAlexander D. Rebchuku00c2 &amp u00c2 Serge MakarenkoDepartment of Pathology &amp Lab Medication, Personnel of Medication, University of British Columbia, Vancouver, British Columbia, CanadaStephen YipDepartment of Neuropathology, Principle of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, GermanyFelix Sahm, u00c2 Felix Sahmu00c2 &amp u00c2 Andreas von DeimlingClinical Cooperation Unit Neuropathology, German Cancer Cells (DKFZ), Heidelberg, GermanyFelix SahmDepartment of Pathology, Leiden University Medical Center, Leiden, The NetherlandsSybren L. N. MaasDepartment of Pathology, Erasmus MC Cancer Institute, Educational Institution Medical Facility Rotterdam, Rotterdam, The NetherlandsSybren L. N. MaasRadiation Medication Plan, Princess Or Queen Margaret Cancer Center, Toronto, Ontario, CanadaDerek S. TsangRadiation Oncology, Utah Cancer Specialists, Salt Lake Area, UT, USAC. Leland RogersCenter for Cancer Cells Research, National Cancer Cells Principle, Bethesda, MD, USAKenneth AldapeMiami Neuroscience Institute, Baptist Health And Wellness, Miami, FL, USAMichael W. McDermottDepartment of Neurosurgery, Addenbrookeu00e2 $ s Medical center, Cambridge, UKThomas Santariusu00c2 &amp u00c2 Daniel M. FountainDepartment of Neurosurgery, University Hospitals Cleveland as well as Situation Western Get University, Cleveland, OH, USAWarren SelmanDepartment of Pathology, College Hospitals Scenario Medical Center, Cleveland, OH, USAMarta CouceDepartment of Neurosurgery, Centro Hospitalar Universitu00c3 u00a1 rio S. Jou00c3 u20a4 o, Porto, PortugalBruno CarvalhoCenter for Neuro-Oncology, Dana-Farber/Brigham as well as Womenu00e2 $ s Cancer cells Facility, Boston, MA, USAPatrick Y. WenDepartment of Neurosurgery, Battle Each Other College, Durham, NC, USAKyle M. WalshDepartment of Neurosurgery, Erasmus MC Cancer Cells Principle, Erasmus College Medical Facility, Rotterdam, The NetherlandsEelke M. BosDepartment of Neurosurgery, Brigham as well as Womenu00e2 $ s Medical facility, Harvard Medical Institution, Boston, MA, USAWenya Linda BiDepartment of Radiology, Brigham and Womenu00e2 $ s Health center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USARaymond Y. HuangDepartment of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical University, Boston Ma, MA, USAPriscilla K. BrastianosDepartment of Radiation Oncology, Massachusetts General Hospital, Boston Ma, MA, USAHelen A. ShihDepartment of Neurology, Hermelin Mind Growth Facility, Holly Ford Health, Detroit, MI, USATobias WalbertDepartment of Neurosurger, Hermelin Human Brain Lump Facility, Holly Ford Wellness, Detroit, MI, USAIan Lee, u00c2 Ana Valeria Castro, u00c2 Houtan Noushmehru00c2 &amp u00c2 James M. SnyderDepartment of Pathology, College of Texas Medical Division, Galveston, TX, USAMichelle M. FelicellaDepartment of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyFrancesco Dimecou00c2 &amp u00c2 Andrea SaladinoNeuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyBianca PolloDepartment of Neurosurgery, LMU Teaching Hospital, LMU Munich, Munich, GermanyChristian Schichoru00c2 &amp u00c2 Ju00c3 u00b6 rg-Christian TonnDepartment of Radiation Oncology, Charitu00c3 u00a9 u00e2 $ "Universitu00c3 $ tsmedizin Berlin, Corporate Participant of Freie Universitu00c3 $ t Berlin and also Humboldt-Universitu00c3 $ t zu Berlin, Berlin, GermanyFelix EhretDepartment of Radiology, Mayo Medical Clinic, Rochester, MN, USATimothy J. KaufmannDepartment of Laboratory Medication as well as Pathology, Mayonnaise Clinic, Rochester, MN, USADaniel H. Lachance, u00c2 Caterina Gianniniu00c2 &amp u00c2 Aditya RaghunathanDepartment of Oncology, Department of Medical Oncology, Mayo Medical Clinic, Rochester, MN, USAEvanthia GalanisDepartments of Neuro-Oncology and Neurosurgery, Moffitt Cancer Facility, Tampa, FL, USAMichael A. VogelbaumNeuropathology System, Surgical Neurology Division, National Principle of Nerve Problems and Movement, National Institutes of Health And Wellness, Bethesda, MD, USAPatrick J. CiminoDepartment of Neurological Surgical Procedure, Northwestern College, Northwestern Medicine, Chicago, IL, USAMark YoungbloodDepartment of Pathology, NYU Langone Medical Center, New York, NY, USAMatija SnuderlDepartment of Radiation Oncology, NYU Langone Health, The Big Apple College, The Big Apple, NY, USAErik P. SulmanDepartment of Neurosurgery, University of Oklahoma Health Sciences Facility, Oklahoma Area, OK, USAIan F. DunnPeninsula Schools of Medicine and also Dentistry, Plymouth College, Plymouth, UKC. Oliver HanemannDepartment of Neurosurgery, Royal College of Surgeons in Ireland, Dublin, IrelandMohsen JavadpourDepartment of Anatomical and also Cellular Pathology, Chinese Educational Institution of Hong Kong, Shatin, Hong KongHo-Keung NgDepartment of Human Genetics, Educational Institution of California, Los Angeles, Los Angeles, CA, USAPaul C. BoutrosDepartment of Neurosurgery, Educational Institution of California, Los Angeles, Los Angeles, USARichard G. EversonDepartment of Neurosurgery, Teaching Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, GreeceAlkiviadis Tzannisu00c2 &amp u00c2 Konstantinos N. FountasDepartment of Neurosurgery, Educational Institution Medical Center Regensburg, Regensburg, GermanyNils Ole SchmidtDepartment of Surgery, Department of Neurosurgery, University of Alberta, Edmonton, Alberta, CanadaKarolyn AuCenter of Neurosurgery, Department of General Neurosurgery, University of Perfume, Cologne, GermanyRoland GoldbrunnerDepartment of Neurology, Faculty of Medicine, University Hospital Fragrance, College of Cologne, Perfume, GermanyNorbert GalldiksLaboratory for Neurooncology as well as Speculative Neurosurgery, Department of General Neurosurgery, Facility for Neurosurgery, Fragrance, GermanyMarco TimmerDepartment of Neurosurgery, Teaching Hospital of Copenhagen-Rigshospitalet, Copenhagen, DenmarkTiit Illimar MathiesenDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyManfred Westphal, u00c2 Katrin Lamszusu00c2 &amp u00c2 Franz L. RicklefsDepartment of Neurosurgery, Teaching Hospital Heidelberg, Heidelberg, GermanyChristel Herold-Mende, u00c2 Christine Jungku00c2 &amp u00c2 Gerhard JungwirthDepartment of Radiation Oncology, Heidelberg Teaching Hospital, Heidelberg, GermanyMaximilian DengLeeds Principle of Medical Analysis at St. Jamesu00e2 $ s, University of Leeds, Leeds, UKSusan C. ShortDepartment of Neurosurgery, The Walton Facility NHS Base Count On, Liverpool, UKMichael D. JenkinsonInstitute of Neuropathology, Otto-Von-Guericke-University, Magdeburg, GermanyChristian MawrinDepartment of Neurosurgery, Manchester Center for Scientific Neurosciences, Salford Royal Medical Center NHS Foundation Count On, Salford, UKAbdurrahman I. Islimu00c2 &amp u00c2 Omar N. PathmanabanDepartment of Neurosurgery, Royal Melbourne Healthcare Facility, Melbourne, VIC, AustraliaKatharine J. Drummondu00c2 &amp u00c2 Andrew MorokoffDepartment of Radiation Oncology, College of The Golden State, San Francisco, San Francisco, CA, USADavid R. RaleighDepartment of Neurosurgery, Educational Institution of California, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Nicholas A. ButowskiDepartment of Pathology, College of The Golden State, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Arie PerrySchool of Drug Sciences of Ribeiru00c3 u20a4 o, Preto Educational institution of Su00c3 u20a4 o Paulo, Su00c3 u20a4 o Paulo, BrazilTathiane M. MaltaDepartment of Pathology and Laboratory Medication, Educational Institution of Saskatchewan College of Medication, Saskatoon, Saskatchewan, CanadaViktor ZherebitskiyDivision of Neurosurgery, Royal Teaching Hospital, Educational Institution of Saskatchewan, Saskatoon, Saskatchewan, CanadaLuke HnennyUSC Pituitary Center, USC Radiosurgery Facility, Keck University of Medication of USC, Los Angeles, CA, USAGabriel ZadaDepartment of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, Hamm, GermanyAntonio SantacroceNuclear Medicine and also Professional Molecular Imaging, Department of Radiology, Eberhard Karls University of Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyChristian la Fougu00c3 u00a8 reDepartment of Neurosurgery, Yale Institution of Medicine, New Shelter, CT, USAJennifer MoliternoDepartment of Neurosurgery, Tufts Medical Center, Boston Ma, MA, USAAlper DincerArthur and Sonia Labatt Human Brain Tumor Investigation Center, The Healthcare Facility for Sick Children, Toronto, Ontario, CanadaGelareh ZadehManuscript composing, figure planning, standard statistical review and also overall bioinformatics were carried out by J.Z.W. Molecular classification, model building as well as bioinformatics support was delivered through V.P., A.P.L. and also J.L. TERT promoter sequencing was conducted by C.G. Replicate amount variant evaluation as well as naming were conducted by A.P.L. Molecular analyte extraction, quantification and also sequencing were performed by J.Z.W., A.P.L., C.G., A.A. and Z.P. DKFZ methylation training class and also subclass resolve was actually carried out through R.Y. and R.K. utilizing the publicly available online resource made by F.S. RNA sequencing review was carried out by V.P. as well as J.L. Biostatistical testimonial was carried out by O.S. Medical information from the NRG Oncology RTOG-0539 meningioma situations were actually given by S.L.P. and also M.W. Clinical meningioma samples and matching scientific data were given through C.W., A.C.G., M.A.Z., G.T., M.T., F.B., D.A.A.B., E.C.H., J.B.S., A.E.S., C.H., S.C., L.B.C., A.R., S.M. and S.Y. Pathologic testimonial was actually executed through A.G. as well as K.A. Radiotherapy data of institutional retrospective meningioma scenarios were actually offered through D.S.T. Study concept as well as perception were actually performed by J.Z.W, F.N. and also G.Z. All of authors took part in document review and also modifications in some ability.

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